Research Fellowship - SRF A

Removal of half the sympathetic innervation does not reduce vasoconstrictor responses in rat tail artery

D Tripovic, EM Mclachlan, JA Brock

2013-06-01

Following reinnervation of denervated rat tail arteries, nerve-evoked contractions are at least as large as those evoked in normal..

Prominent contribution of L-type ca 2 channels to cutaneous neurovascular transmission that is revealed after spinal cord injury augments vasoconstriction

HA Dera, MD Habgood, JB Furness, JA Brock

2012-02-01

In patients with spinal cord injury (SCI), somatosympathetic reflexes produce exaggerated decreases in skin blood flow below the l..

Nerve-evoked constriction of rat tail veins is potentiated and venous diameter is reduced after chronic spinal cord transection

D Tripovic, A Al Abed, NM Rummery, NJ Johansen, EM McLachlan, JA Brock

2011-05-01

Despite reduced sympathetic activity below the level of a spinal cord injury (SCI), venoconstriction during autonomic dysreflexia ..

Two mechanisms underlie the slow noradrenergic depolarization in the rat tail artery in vitro

NM Rummery, JA Brock

2011-01-20

In rat tail artery, short trains of electrical stimuli evoke both ATP-mediated excitatory junction potentials (EJPs) and a slow no..

Slow and incomplete sympathetic reinnervation of rat tail artery restores the amplitude of nerve-evoked contractions provided a perivascular plexus is present

D Tripovic, S Pianova, EM McLachlan, JA Brock

2011-01-01

We have investigated the recovery of sympathetic control following reinnervation of denervated rat tail arteries by relating the r..

Sympathetic vasoconstriction is potentiated in arteries caudal but not rostral to a spinal cord transection in rats

NM Rummery, D Tripovic, EM McLachlan, JA Brock

2010-11-01

Sympathetic nerve-mediated contractions of mesenteric and tail arteries controlled by preganglionic neurones decentralized by a sp..

Evidence for functional ghrelin receptors on parasympathetic preganglionic neurons of micturition control pathways in the rat

DM Ferens, L Yin, K Ohashi-Doi, M Habgood, R Bron, JA Brock, JD Gale, JB Furness

2010-09-01

1. Previous work indicates that agonists of ghrelin receptors can act within the spinal cord to stimulate autonomic outputs to the..

Characterization of NaV1.6-mediated Na currents in smooth muscle cells isolated from mouse vas deferens

HL Zhu, A Shibata, T Inai, M Nomura, Y Shibata, JA Brock, N Teramoto

2010-04-01

Patch-clamp experiments were performed to investigate the behavior of voltage-activated inward currents in vas deferens myocytes f..

Transient supersensitivity to α-adrenoceptor agonists, and distinct hyper-reactivity to vasopressin and angiotensin II after denervation of rat tail artery

D Tripovic, S Pianova, EM McLachlan, JA Brock

2010-01-01

Background and purpose: Vascular 'denervation' hyper-reactivity has generally been investigated 1-2 weeks after administration of ..

Inhibition of KATP channels in the rat tail artery by neurally released noradrenaline acting on postjunctional α2-adrenoceptors

JH Tan, A Al Abed, JA Brock

2007-06-01

In rat tail artery, activation of postjunctional α<inf>2</inf> -adrenoceptors by noradrenaline (NA) released from sympathetic axon..

Postnatal androgen deprivation dissociates the development of smooth muscle innervation from functional neurotransmission in mouse vas deferens

JA Brock, DJ Handelsman, JR Keast

2007-06-01

The pelvic autonomic nervous system is a target for circulating androgens in adults, with androgen exposure or deprivation affecti..

Rho kinase inhibitors reduce neurally evoked contraction of the rat tail artery in vitro

M Yeoh, JA Brock

2005-11-01

1 The effects of Rho kinase inhibitors (Y27632, HA-1077) on contractions to electrical stimulation and to application of phenyleph..